Drug safety notice: Pabrinex (Vitamins B and C) Intravenous High Potency Solution for injection ampoules

April 30, 2024

There is currently a shortage of the following medications:

Parinex Intravenous ( IV) injection is out of stock in Pharmacy and no stock is available from suppliers, until at least September 2025.
Pabrinex (Vitamins B and C) Intramuscular (IM) High Potency Solution for injection
ampoules have been discontinued.
There are no other licensed parenteral alternatives to Pabrinex® IV injections

Advice/alternative arrangements:

Ensure any Pabrinex IV is only being used within national clinical guidelines.
Thiamine 50mg and 100mg tablets remain available and should be used where clinically
appropriate.
Solivito N powder for concentrate for solution for infusion vials cannot support an uplift in demand.
Note that the Department of Health and Social Care and NHS England are convening a clinical reference group of key stakeholders to develop and share additional guidance in due course.
Additionally, they are working with importers/ suppliers to source alternative products including unlicensed thiamine injections, further information will be provided once available.

Actions:

All clinicians should urgently review any patients prescribed Pabrinex IV to ensure it is
only being used within national clinical guidelines in terms of dose and length of course.
The aim should be to reduce the usage of Pabrinex IV and maintain stocks for essential use only.

For more information please contact the pharmacy department on ext. 5263/3783.